In Phase 2 detoxification, various enzymes act directly on the toxic substances partially degraded and processed in Phase 1, such as heavy metals and organo-toxins, by binding them with protective compounds, thereby either inactivating the toxins
Zinc PCA regulates oil production 4
Very dry skin, however, might benefit more from formulations with lipid-based vehicles for better absorption
PRCA is sometimes reversible with dose reduction or withdrawal of the drug
Ethics statement The animal study was reviewed and approved by the Committee for the Purpose of Control and Supervision of Experiments on Animals (CPCSEA), New Delhi, India, and the Departmental Animal Ethical Committee (DAEC) of the University of Rajasthan, Centre for Advanced studies (CAS), Jaipur, India, has approved this study vide approval number 1678/90/re/S/12/CPCSEA dated 16 June, 2017
While kojic acid is generally considered safer than hydroquinone, pregnant and breastfeeding women should consult their healthcare provider before use